MLB scores: Wednesday, September 22, 2021
2026 MLB playoffs: bracket and every series →- Pittsburgh Pirates at Cincinnati Reds
Postponed · Great American Ball Park
- Chicago White Sox at Detroit Tigers
Postponed · Comerica Park
- Toronto Blue Jays at Tampa Bay Rays final score and box score
Final · Tropicana Field
- Kansas City Royals at Cleveland Guardians
Postponed · Progressive Field
- Washington Nationals at Miami Marlins final score and box score
Final · loanDepot park
- Baltimore Orioles at Philadelphia Phillies final score and box score
Final · Citizens Bank Park
- Texas Rangers at New York Yankees final score and box score
Final · Yankee Stadium
- New York Mets at Boston Red Sox final score and box score
Final · Fenway Park · ESPN
- Minnesota Twins at Chicago Cubs final score and box score
Final · Wrigley Field
- St. Louis Cardinals at Milwaukee Brewers final score and box score
Final · American Family Field
- Los Angeles Dodgers at Colorado Rockies final score and box score
Final · Coors Field
- Houston Astros at Los Angeles Angels final score and box score
Final · Angel Stadium · ESPN+
- Atlanta Braves at Arizona Diamondbacks final score and box score
Final · Chase Field
- Seattle Mariners at Athletics final score and box score
Final · Oakland Coliseum
- San Francisco Giants at San Diego Padres final score and box score
Final · Petco Park · ESPN
