Players who played for the Buffalo Bills and San Francisco 49ers
34 players
34 players have played for both the Buffalo Bills and the San Francisco 49ers. Frank Gore spent the most seasons with the two: 1 with the Buffalo Bills and 10 with the San Francisco 49ers. On a roster now: Siran Neal, Mitch Wishnowsky, and Trent Sherfield. Rosters are on file in full from 1993; before that only some of the stars are.
| Player | Pos | BUF | SF |
|---|---|---|---|
| Frank Gore | RB | 2019 · 1 season | 2005–2014 · 10 seasons |
| Nate Clements | SS | 2001–2006 · 6 seasons | 2007–2010 · 4 seasons |
| Terrell Owens | WR | 2009 · 1 season | 1996–2003 · 8 seasons |
| Ted Washington | DT | 1995–2000 · 6 seasons | 1991–1993 · 3 seasons |
| Siran Neal | S | 2018–2023 · 6 seasons | 2025–2026 · 2 seasons |
| Manny Lawson | LB | 2013–2015 · 3 seasons | 2006–2010 · 5 seasons |
| Donte Whitner | DB | 2006–2010 · 5 seasons | 2011–2013 · 3 seasons |
| Mitch Wishnowsky | P | 2025 · 1 season | 2019–2024 · 6 seasons |
| Marquise Goodwin | WR | 2013–2016 · 4 seasons | 2017–2019 · 3 seasons |
| Stevie Johnson | WR | 2008–2013 · 6 seasons | 2014 · 1 season |
| Takeo Spikes | LB | 2003–2006 · 4 seasons | 2008–2010 · 3 seasons |
| Boobie Dixon | RB | 2014–2015 · 2 seasons | 2010–2013 · 4 seasons |
| Jonas Jennings | OT | 2001–2004 · 4 seasons | 2005–2006 · 2 seasons |
| Jeff Posey | LB | 2003–2005 · 3 seasons | 1998–2000 · 3 seasons |
| Pierson Prioleau | S | 2001–2004 · 4 seasons | 1999–2000 · 2 seasons |
| Sean Moran | DE | 1996–1999 · 4 seasons | 2002–2003 · 2 seasons |
| Jason Webster | CB | 2007 · 1 season | 2000–2003 · 4 seasons |
| Matt Breida | RB | 2021 · 1 season | 2017–2019 · 3 seasons |
| Tony Cline | TE | 1995–1997 · 3 seasons | 1999 · 1 season |
| Josh Norman | CB | 2020–2023 · 2 seasons | 2021 · 1 season |
| Tyler Kroft | TE | 2019–2020 · 2 seasons | 2022 · 1 season |
| Blake Costanzo | LB | 2007–2008 · 2 seasons | 2011 · 1 season |
| Kevin R. Williams | WR | 1998–1999 · 2 seasons | 2000 · 1 season |
| Oliver Barnett | DE | 1993–1994 · 2 seasons | 1995 · 1 season |
| Leonard Floyd | DE | 2023 · 1 season | 2024 · 1 season |
| Trent Sherfield | WR | 2023 · 1 season | 2021 · 1 season |
| Emmanuel Sanders | WR | 2021 · 1 season | 2019 · 1 season |
| Jordan Matthews | TE | 2017 · 1 season | 2019 · 1 season |
| Jeremy Kerley | WR | 2018 · 1 season | 2016 · 1 season |
| Leger Douzable | DT | 2016 · 1 season | 2017 · 1 season |
| Travaris Cadet | RB | 2017 · 1 season | 2015 · 1 season |
| Reggie Bush | RB | 2016 · 1 season | 2015 · 1 season |
| Chris Draft | LB | 2009 · 1 season | 1999 · 1 season |
| Chidi Ahanotu | DE | 2002 · 1 season | 2003 · 1 season |
Regular season, under every name each club has played as. A season split by a trade counts for both clubs where the game logs reach it (NBA from 1993-94, NFL 1994, NHL 1996, MLB 2001). Longest stay with the two first.