Buffalo Bills vs San Francisco 49ers head-to-head
Who has won more, the Buffalo Bills or the San Francisco 49ers?
Buffalo Bills lead the series 8-6 in 14 meetings since Sep 24, 1972. They average 21.6 to 21.6. The last meeting was Dec 1, 2024, 35-10.
- Record
- Buffalo Bills 8-6 San Francisco 49ers
- Games
- 14
- Points per game
- 21.6 – 21.6
- Biggest win
- San Francisco 49ers by 42
Buffalo Bills have won the last 3 meetings.
Every meeting on file
| Dec 1, 2024 |  SF at  BUF | 10-35 | Buffalo Bills | Regular |
| Dec 7, 2020 | BUF at SF | 34-24 | Buffalo Bills | Regular |
| Oct 16, 2016 | SF at BUF | 16-45 | Buffalo Bills | Regular |
| Oct 7, 2012 | BUF at SF | 3-45 | San Francisco 49ers | Regular |
| Nov 30, 2008 | SF at BUF | 10-3 | San Francisco 49ers | Regular |
| Dec 26, 2004 | BUF at SF | 41-7 | Buffalo Bills | Regular |
| Dec 2, 2001 | BUF at SF | 0-35 | San Francisco 49ers | Regular |
| Oct 4, 1998 | SF at BUF | 21-26 | Buffalo Bills | Regular |
| Dec 3, 1995 | BUF at SF | 17-27 | San Francisco 49ers | Regular |
| Sep 13, 1992 | BUF at SF | 34-31 | Buffalo Bills | Regular |
| Dec 17, 1989 | BUF at SF | 10-21 | San Francisco 49ers | Regular |
| Dec 11, 1983 | SF at BUF | 23-10 | San Francisco 49ers | Regular |
| Dec 21, 1980 | BUF at SF | 18-13 | Buffalo Bills | Regular |
| Sep 24, 1972 | SF at BUF | 20-27 | Buffalo Bills | Regular |
Completed games on file, which start in 1972 — not the clubs’ full all-time series. Regular season 14, postseason 0.