Brett Favre | QB | 1991–2010 | 20 | 302 GP · 71,838 pass yds | Gulfport, MS |
| Jerry Rice | WR | 1985–2004 | 20 | 292 GP · 22,895 rec yds | Crawford, MS |
| Terrell Buckley | DB | 1992–2004 | 13 | 205 GP · 497 tackles, 2 sacks | Pascagoula, MS |
Deshea Townsend | CB | 1998–2010 | 13 | 191 GP · 449 tackles, 15.5 sacks | Batesville, MS |
| Wesley Walls | TE | 1989–2003 | 13 | 190 GP · 5,291 rec yds | Batesville, MS |
Fletcher Cox | DT | 2012–2023 | 12 | 188 GP · 519 tackles, 70 sacks | Yazoo City, MS |
| Fred McAfee | RB | 1991–2006 | 15 | 187 GP · 1,273 rush yds | Philadelphia, MS |
| Eric Moulds | WR | 1996–2007 | 12 | 186 GP · 9,995 rec yds | Lucedale, MS |
Reggie Kelly | TE | 1999–2011 | 12 | 184 GP · 1,767 rec yds | Aberdeen, MS |
| Steve McNair | QB | 1995–2007 | 13 | 161 GP · 31,304 pass yds | Mount Olive, MS |
K.J. Wright | LB | 2011–2021 | 11 | 161 GP · 992 tackles, 13.5 sacks | Olive Branch, MS |
Jason Ferguson | DT | 1997–2009 | 12 | 159 GP · 496 tackles, 21.5 sacks | Nettleton, MS |
Glover Quin | S | 2009–2018 | 10 | 159 GP · 737 tackles, 4 sacks | Summit, MS |
| Tim Bowens | DT | 1994–2004 | 11 | 157 GP · 401 tackles, 22 sacks | Okolona, MS |
| Fred Thomas | CB | 1996–2007 | 12 | 156 GP · 517 tackles, 5 sacks | Bruce, MS |
Tommy Kelly | DE | 2004–2014 | 11 | 150 GP · 475 tackles, 37.5 sacks | Jackson, MS |
| Dexter McCleon | DB | 1997–2006 | 10 | 148 GP · 373 tackles, 4.5 sacks | Meridian, MS |
Stephen Gostkowski | PK | 2006–2020 | 15 | 147 GP · 26 tackles | Madison, MS |
| Carlos Emmons | LB | 1996–2006 | 11 | 147 GP · 644 tackles, 19 sacks | Greenwood, MS |
| Jeff Posey | LB | 1998–2006 | 9 | 139 GP · 337 tackles, 20.5 sacks | Bassfield, MS |
| Michael Myers | DT | 1998–2007 | 10 | 138 GP · 316 tackles, 15.5 sacks | Vicksburg, MS |
| Ken Lucas | CB | 2001–2009 | 9 | 138 GP · 529 tackles | Cleveland, MS |
| Larry Whigham | DB | 1994–2002 | 9 | 136 GP · 184 tackles, 5 sacks | Hattiesburg, MS |
Donald Lee | TE | 2003–2011 | 9 | 133 GP · 1,990 rec yds | Maben, MS |
Mario Haggan | LB | 2003–2012 | 10 | 132 GP · 283 tackles, 9 sacks | Clarksdale, MS |
| Chris Burkett | WR | 1985–1993 | 9 | 131 GP · 4,352 rec yds | Laurel, MS |
| Fred Smoot | CB | 2001–2009 | 9 | 129 GP · 446 tackles | Jackson, MS |
| Kris Mangum | TE | 1997–2006 | 10 | 126 GP · 1,424 rec yds | Magee, MS |
Jamie Collins Sr. | LB | 2013–2022 | 10 | 125 GP · 709 tackles, 26.5 sacks | Mc Call Creek, MS |
Spencer Johnson | DT | 2004–2012 | 9 | 125 GP · 303 tackles, 14 sacks | Waynesboro, MS |
Tramaine Brock | CB | 2010–2020 | 11 | 118 GP · 267 tackles | Long Beach, MS |
Parys Haralson | DE | 2006–2014 | 8 | 118 GP · 267 tackles, 28 sacks | Flora, MS |
| Kevin Henry | DE | 1993–2000 | 8 | 117 GP · 226 tackles, 14 sacks | Mound Bayou, MS |
| Aubrey Derron Matthews | WR | 1986–1996 | 11 | 115 GP · 2,112 rec yds | Pascagoula, MS |
| Eric Warfield | DB | 1998–2005 | 8 | 115 GP · 373 tackles, 1 sacks | Vicksburg, MS |
| Stevon Moore | DB | 1992–1999 | 8 | 115 GP · 523 tackles, 3 sacks | Wiggins, MS |
| Darion Conner | DE | 1990–1997 | 8 | 114 GP · 149 tackles, 33 sacks | Macon, MS |
| Richard Harvey | LB | 1993–2000 | 8 | 114 GP · 370 tackles, 13 sacks | Pascagoula, MS |
Clinton Portis | RB | 2002–2010 | 9 | 113 GP · 9,923 rush yds | Laurel, MS |
| Dwayne Rudd | LB | 1997–2003 | 7 | 109 GP · 504 tackles, 11.5 sacks | Batesville, MS |
| Tony Bennett | DE | 1990–1997 | 8 | 108 GP · 233 tackles, 64.5 sacks | Alligator, MS |
| James E. Williams | LB | 1991–1999 | 7 | 107 GP · 239 tackles, 3 sacks | Natchez, MS |
Correll Buckhalter | RB | 2001–2010 | 7 | 103 GP · 2,944 rush yds | Collins, MS |
J.T. Gray | S | 2018–2025 | 8 | 102 GP · 106 tackles, 2.5 sacks | Clarksdale, MS |
Malcolm Butler | CB | 2014–2020 | 7 | 100 GP · 406 tackles, 3 sacks | Vicksburg, MS |
Quentin Groves | LB | 2008–2014 | 7 | 100 GP · 175 tackles, 9.5 sacks | Greenville, MS |
| Alvin McKinley | DT | 2000–2007 | 8 | 97 GP · 231 tackles, 11.5 sacks | Jackson, MS |
| Deuce McAllister | RB | 2001–2008 | 8 | 97 GP · 6,096 rush yds | Lena, MS |
| Fred Barnett | WR | 1990–1997 | 8 | 96 GP · 5,362 rec yds | Shelby, MS |
Justin Griffith | FB | 2003–2009 | 7 | 96 GP · 989 rec yds | Magee, MS |
Boobie Dixon | RB | 2010–2015 | 6 | 96 GP · 934 rush yds | Jackson, MS |
| Ellis Wyms | DT | 2001–2008 | 8 | 95 GP · 139 tackles, 19 sacks | Indianola, MS |
Cooper Carlisle | OG | 2003–2012 | 7 | 95 GP · 9 tackles | Greenville, MS |
Jamarca Sanford | S | 2009–2015 | 7 | 95 GP · 297 tackles, 1 sacks | Batesville, MS |
Charlie Anderson | LB | 2004–2009 | 6 | 92 GP · 122 tackles, 7.5 sacks | Jackson, MS |
Benardrick McKinney | LB | 2015–2021 | 7 | 91 GP · 559 tackles, 11.5 sacks | Tunica, MS |
Jason Campbell | QB | 2006–2014 | 9 | 90 GP · 16,771 pass yds | Laurel, MS |
| John Mangum | DB | 1991–1998 | 7 | 90 GP · 206 tackles, 4.5 sacks | Magee, MS |
Cedric Griffin | SS | 2006–2012 | 7 | 89 GP · 412 tackles | Natchez, MS |
| Milton Mack | DB | 1987–1994 | 7 | 87 GP · 45 tackles, 2 sacks | Jackson, MS |
C.C. Brown | S | 2005–2011 | 7 | 83 GP · 373 tackles, 1 sacks | Greenwood, MS |
Antonio Johnson | DL | 2008–2013 | 6 | 83 GP · 143 tackles, 4.5 sacks | Leland, MS |
Donte Moncrief | WR | 2014–2020 | 7 | 80 GP · 2,576 rec yds | Raleigh, MS |
Brandon McDonald | DB | 2007–2012 | 6 | 78 GP · 216 tackles, 1 sacks | Collins, MS |
| Robert Young | DE | 1991–1996 | 6 | 78 GP · 76 tackles, 20.5 sacks | Jackson, MS |
| Todd Pinkston | WR | 2000–2004 | 5 | 78 GP · 2,816 rec yds | Forest, MS |
| Marlo Perry | LB | 1994–1999 | 6 | 76 GP · 179 tackles, 1.5 sacks | Forest, MS |
Tom Johnson | DT | 2014–2018 | 5 | 76 GP · 132 tackles, 20.5 sacks | Moss Point, MS |
Stevan Ridley | RB | 2011–2018 | 8 | 73 GP · 3,102 rush yds | Natchez, MS |
Chris Spencer | C | 2006–2014 | 6 | 73 GP · 8 tackles | Madison, MS |
| Mario Edwards | CB | 2000–2004 | 5 | 73 GP · 175 tackles | Gautier, MS |
| Antuan Edwards | DB | 1999–2005 | 7 | 71 GP · 233 tackles, 3 sacks | Starkville, MS |
Benito Jones | DT | 2020–2025 | 5 | 71 GP · 83 tackles, 3.5 sacks | Waynesboro, MS |
| Tank Williams | S | 2002–2007 | 5 | 70 GP · 283 tackles, 3.5 sacks | Gulfport, MS |
| Russell Copeland | WR | 1993–1998 | 5 | 69 GP · 1,460 rec yds | Tupelo, MS |
| Mark Smith | DT | 1997–2002 | 6 | 67 GP · 191 tackles, 20 sacks | Vicksburg, MS |
Jerious Norwood | RB | 2006–2011 | 6 | 66 GP · 2,056 rush yds | Jackson, MS |
| Kendall Simmons | OG | 2002–2008 | 5 | 64 GP · 10 tackles | Ripley, MS |
| Louis Green | LB | 2004–2008 | 5 | 64 GP · 44 tackles | Vicksburg, MS |
Alejandro Villanueva | OT | 2015–2018 | 4 | 64 GP · 4 tackles | Biloxi, MS |
Gabe Jackson | G | 2014–2020 | 5 | 61 GP · 7 tackles | Liberty, MS |
Chris Givens | WR | 2012–2015 | 4 | 60 GP · 1,779 rec yds | Jackson, MS |
Alex Carrington | DE | 2010–2015 | 6 | 59 GP · 62 tackles, 4 sacks | Tupelo, MS |
Cam Akers | RB | 2020–2025 | 6 | 59 GP · 2,044 rush yds | Clinton, MS |
Micheal Spurlock | WR | 2006–2014 | 8 | 58 GP · 502 rec yds | Indianola, MS |
| Dennis McKinley | RB | 1999–2002 | 4 | 58 GP · 12 tackles | Kosciusko, MS |
| Kenyatta Walker | OT | 2002–2005 | 4 | 56 GP · 7 tackles | Meridian, MS |
Johnathan Abram | S | 2019–2024 | 6 | 55 GP · 311 tackles | Columbia, MS |
| Cedric Tillman | WR | 1992–1995 | 4 | 52 GP · 1,227 rec yds | Natchez, MS |
Stephen Peterman | OG | 2007–2010 | 4 | 52 GP · 7 tackles | Gulfport, MS |
| Pat Coleman | WR | 1990–1994 | 5 | 51 GP · 575 rec yds | Cleveland, MS |
Chris White | LB | 2011–2014 | 4 | 51 GP · 35 tackles | Vancleave, MS |
| Reggie Myles | CB | 2002–2005 | 4 | 51 GP · 55 tackles | Pascagoula, MS |
| Todd Wade | OT | 2001–2007 | 4 | 51 GP · 4 tackles | Greenwood, MS |
| William Gaines | DT | 1994–1997 | 4 | 51 GP · 70 tackles, 2 sacks | Jackson, MS |
Floyd Womack | OG | 2003–2008 | 5 | 50 GP · 5 tackles | Cleveland, MS |
Johnthan Banks | CB | 2013–2017 | 5 | 50 GP · 142 tackles | Maben, MS |
| Irving Spikes | RB | 1994–1997 | 4 | 48 GP · 934 rush yds | Ocean Springs, MS |
| John Baylor | SS | 1991–1993 | 3 | 48 GP · 33 tackles, 4 sacks | Meridian, MS |
| Marc Woodard | LB | 1994–1996 | 3 | 48 GP · 38 tackles, 1.5 sacks | Kosciusko, MS |