Minnesota Twins players with 300+ career HR
13 players
13 players with 300+ career HR played for the Minnesota Twins. Jim Thome leads with 612 home runs.
| Player | Pos | With club | Career |
|---|---|---|---|
| Jim Thome | DH | 2010–2011 | 612 |
| Harmon Killebrew | — | 1954–1974 | 573 |
| David Ortiz | DH | 1997–2002 | 541 |
| Dave Winfield | DH | 1993–1994 | 465 |
| Nelson Cruz | DH | 2019–2021 | 464 |
| Graig Nettles | 3B | 1967–1969 | 390 |
| Gary Gaetti | DH | 1981–1990 | 360 |
| Torii Hunter | RF | 1998–2015 | 353 |
| Chili Davis | DH | 1991–1992 | 350 |
| Carlos Santana | 1B | 2024 | 335 |
| Roy Sievers | — | 1954–1959 | 318 |
| Al Simmons | — | 1937–1938 | 307 |
| Ruben Sierra | DH | 2006 | 306 |
The career total counts wherever it was made, as the Immaculate Grid counts it: one season with the club is enough. Every season since 1876 is on file. A season split between two clubs is filed as one combined line and counts for neither.