Chicago White Sox players with 300+ career HR
23 players
23 players with 300+ career HR played for the Chicago White Sox. Ken Griffey Jr. leads with 630 home runs.
| Player | Pos | With club | Career |
|---|---|---|---|
| Ken Griffey Jr. | DH | 2008 | 630 |
| Jim Thome | DH | 2006–2009 | 612 |
| Sammy Sosa | DH | 1990–1991 | 609 |
| Manny Ramirez | LF | 2010 | 555 |
| Frank Thomas | DH | 1990–2005 | 521 |
| Adam Dunn | DH | 2011–2014 | 462 |
| Jose Canseco | DH | 2001 | 462 |
| Paul Konerko | DH | 1999–2014 | 439 |
| Andruw Jones | LF | 2010 | 434 |
| Edwin Encarnacion | DH | 2020 | 424 |
| Harold Baines | DH | 1980–2001 | 384 |
| Albert Belle | LF | 1997–1998 | 381 |
| Norm Cash | — | 1958–1959 | 377 |
| Carlton Fisk | C | 1981–1993 | 376 |
| Carlos Lee | 1B | 1999–2004 | 358 |
| Ellis Burks | DH | 1993 | 352 |
| Dick Allen | — | 1972–1974 | 351 |
| Ron Santo | — | 1974 | 342 |
| Jermaine Dye | RF | 2005–2009 | 325 |
| Roy Sievers | — | 1960–1961 | 318 |
| Al Simmons | — | 1933–1935 | 307 |
| Greg Luzinski | DH | 1981–1984 | 307 |
| Ruben Sierra | DH | 1998 | 306 |
The career total counts wherever it was made, as the Immaculate Grid counts it: one season with the club is enough. Every season since 1876 is on file. A season split between two clubs is filed as one combined line and counts for neither.