Cleveland Guardians vs St. Louis Cardinals head-to-head
Who has won more, the Cleveland Guardians or the St. Louis Cardinals?
Cleveland Guardians lead the series 25-23 in 48 meetings since Jun 14, 1997. They average 4.8 to 3.9. The last meeting was Apr 15, 2026, 5-3.
- Record
- Cleveland Guardians 25-23 St. Louis Cardinals
- Games
- 48
- Points per game
- 4.8 – 3.9
- Biggest win
- Cleveland Guardians by 12
St. Louis Cardinals have won the last 2 meetings.
Every meeting on file
| Apr 15, 2026 |  CLE at  STL | 3-5 | St. Louis Cardinals | Regular |
| Apr 14, 2026 | CLE at STL | 5-6 | St. Louis Cardinals | Regular |
| Apr 13, 2026 | CLE at STL | 9-3 | Cleveland Guardians | Regular |
| Jun 29, 2025 | STL at CLE | 7-0 | St. Louis Cardinals | Regular |
| Jun 28, 2025 | STL at CLE | 9-6 | St. Louis Cardinals | Regular |
| Jun 27, 2025 | STL at CLE | 5-0 | St. Louis Cardinals | Regular |
| Sep 22, 2024 | CLE at STL | 1-2 | St. Louis Cardinals | Regular |
| Sep 21, 2024 | CLE at STL | 5-6 | St. Louis Cardinals | Regular |
| Sep 20, 2024 | CLE at STL | 5-1 | Cleveland Guardians | Regular |
| May 28, 2023 | STL at CLE | 3-4 | Cleveland Guardians | Regular |
| May 27, 2023 | STL at CLE | 2-1 | St. Louis Cardinals | Regular |
| May 26, 2023 | STL at CLE | 3-4 | Cleveland Guardians | Regular |
| Jul 28, 2021 | STL at CLE | 2-7 | Cleveland Guardians | Regular |
| Jul 27, 2021 | STL at CLE | 4-2 | St. Louis Cardinals | Regular |
| Jun 9, 2021 | CLE at STL | 2-8 | St. Louis Cardinals | Regular |
| Jun 8, 2021 | CLE at STL | 10-1 | Cleveland Guardians | Regular |
| Aug 30, 2020 | CLE at STL | 2-7 | St. Louis Cardinals | Regular |
| Aug 29, 2020 | CLE at STL | 2-1 | Cleveland Guardians | Regular |
| Aug 28, 2020 | CLE at STL | 14-2 | Cleveland Guardians | Regular |
| Jun 27, 2018 | CLE at STL | 5-1 | Cleveland Guardians | Regular |
| Jun 26, 2018 | CLE at STL | 2-11 | St. Louis Cardinals | Regular |
| Jun 25, 2018 | CLE at STL | 0-4 | St. Louis Cardinals | Regular |
| May 14, 2015 | STL at CLE | 2-1 | St. Louis Cardinals | Regular |
| May 13, 2015 | STL at CLE | 0-2 | Cleveland Guardians | Regular |
| May 12, 2015 | STL at CLE | 8-3 | St. Louis Cardinals | Regular |
| Jun 10, 2012 | CLE at STL | 4-1 | Cleveland Guardians | Regular |
| Jun 9, 2012 | CLE at STL | 0-2 | St. Louis Cardinals | Regular |
| Jun 8, 2012 | CLE at STL | 6-2 | Cleveland Guardians | Regular |
| Jun 14, 2009 | STL at CLE | 0-3 | Cleveland Guardians | Regular |
| Jun 13, 2009 | STL at CLE | 3-1 | St. Louis Cardinals | Regular |
| Jun 12, 2009 | STL at CLE | 3-7 | Cleveland Guardians | Regular |
| Mar 31, 2007 | CLE at STL | 1-5 | St. Louis Cardinals | Preseason |
| Jun 28, 2006 | CLE at STL | 4-5 | St. Louis Cardinals | Regular |
| Jun 27, 2006 | CLE at STL | 3-1 | Cleveland Guardians | Regular |
| Jun 26, 2006 | CLE at STL | 10-3 | Cleveland Guardians | Regular |
| Jul 8, 2001 | STL at CLE | 4-3 | St. Louis Cardinals | Regular |
| Jul 7, 2001 | STL at CLE | 6-7 | Cleveland Guardians | Regular |
| Jul 6, 2001 | STL at CLE | 2-14 | Cleveland Guardians | Regular |
| Jun 4, 2000 | CLE at STL | 3-2 | Cleveland Guardians | Regular |
| Jun 3, 2000 | CLE at STL | 4-2 | Cleveland Guardians | Regular |
| Jun 2, 2000 | CLE at STL | 1-5 | St. Louis Cardinals | Regular |
| Mar 26, 2000 | STL at CLE | 15-11 | St. Louis Cardinals | Preseason |
| Mar 14, 2000 | CLE at STL | 11-6 | Cleveland Guardians | Preseason |
| Jun 25, 1998 | STL at CLE | 2-8 | Cleveland Guardians | Regular |
| Jun 24, 1998 | STL at CLE | 3-14 | Cleveland Guardians | Regular |
| Jun 15, 1997 | CLE at STL | 9-2 | Cleveland Guardians | Regular |
| Jun 14, 1997 | CLE at STL | 8-3 | Cleveland Guardians | Regular |
| Jun 14, 1997 | CLE at STL | 2-5 | St. Louis Cardinals | Regular |
Completed games on file, which start in 1997 — not the clubs’ full all-time series. Regular season 48, postseason 0.