Chicago White Sox vs San Diego Padres head-to-head
Who has won more, the Chicago White Sox or the San Diego Padres?
San Diego Padres lead the series 51-31 in 85 meetings since Mar 9, 2000. They average 4.4 to 4.8. The last meeting was May 3, 2026, 4-3.
- Record
- Chicago White Sox 31-51-3 San Diego Padres
- Games
- 85
- Points per game
- 4.4 – 4.8
- Biggest win
- San Diego Padres by 11
Every meeting on file
| May 3, 2026 |  CHW at  SD | 3-4 | San Diego Padres | Regular |
| May 2, 2026 | CHW at SD | 4-0 | Chicago White Sox | Regular |
| May 1, 2026 | CHW at SD | 8-2 | Chicago White Sox | Regular |
| Mar 19, 2026 | CHW at SD | 6-13 | San Diego Padres | Preseason |
| Mar 3, 2026 | SD at CHW | 4-3 | San Diego Padres | Preseason |
| Sep 21, 2025 | SD at CHW | 3-2 | San Diego Padres | Regular |
| Sep 20, 2025 | SD at CHW | 7-3 | San Diego Padres | Regular |
| Sep 19, 2025 | SD at CHW | 3-4 | Chicago White Sox | Regular |
| Mar 11, 2025 | CHW at SD | 5-7 | San Diego Padres | Preseason |
| Feb 26, 2025 | SD at CHW | 3-1 | San Diego Padres | Preseason |
| Sep 22, 2024 | CHW at SD | 2-4 | San Diego Padres | Regular |
| Sep 21, 2024 | CHW at SD | 2-6 | San Diego Padres | Regular |
| Sep 20, 2024 | CHW at SD | 2-3 | San Diego Padres | Regular |
| Mar 9, 2024 | CHW at SD | 1-1 | Chicago White Sox | Preseason |
| Feb 28, 2024 | SD at CHW | 3-1 | San Diego Padres | Preseason |
| Oct 1, 2023 | SD at CHW | 2-1 | San Diego Padres | Regular |
| Sep 30, 2023 | SD at CHW | 6-1 | San Diego Padres | Regular |
| Sep 29, 2023 | SD at CHW | 3-2 | San Diego Padres | Regular |
| Mar 11, 2023 | CHW at SD | 5-6 | San Diego Padres | Preseason |
| Feb 25, 2023 | SD at CHW | 6-2 | San Diego Padres | Preseason |
| Oct 2, 2022 | CHW at SD | 2-1 | Chicago White Sox | Regular |
| Oct 1, 2022 | CHW at SD | 2-5 | San Diego Padres | Regular |
| Sep 30, 2022 | CHW at SD | 3-1 | Chicago White Sox | Regular |
| Apr 5, 2022 | CHW at SD | 9-6 | Chicago White Sox | Preseason |
| Mar 28, 2022 | SD at CHW | 9-8 | San Diego Padres | Preseason |
| Mar 16, 2021 | CHW at SD | 4-3 | Chicago White Sox | Preseason |
| Mar 9, 2021 | SD at CHW | 4-2 | San Diego Padres | Preseason |
| Mar 8, 2020 | CHW at SD | 6-0 | Chicago White Sox | Preseason |
| Mar 2, 2020 | SD at CHW | 3-1 | San Diego Padres | Preseason |
| Mar 5, 2019 | SD at CHW | 7-4 | San Diego Padres | Preseason |
| Feb 24, 2019 | CHW at SD | 4-5 | San Diego Padres | Preseason |
| Mar 21, 2018 | SD at CHW | 4-3 | San Diego Padres | Preseason |
| Mar 9, 2018 | CHW at SD | 0-2 | San Diego Padres | Preseason |
| Mar 4, 2018 | SD at CHW | 7-6 | San Diego Padres | Preseason |
| May 14, 2017 | SD at CHW | 3-9 | Chicago White Sox | Regular |
| May 13, 2017 | SD at CHW | 4-5 | Chicago White Sox | Regular |
| May 12, 2017 | SD at CHW | 6-3 | San Diego Padres | Regular |
| Mar 29, 2017 | SD at CHW | 9-9 | San Diego Padres | Preseason |
| Mar 6, 2017 | SD at CHW | 6-5 | San Diego Padres | Preseason |
| Mar 3, 2017 | CHW at SD | 3-1 | Chicago White Sox | Preseason |
| Apr 2, 2016 | CHW at SD | 10-2 | Chicago White Sox | Preseason |
| Apr 1, 2016 | CHW at SD | 5-3 | Chicago White Sox | Preseason |
| Mar 23, 2016 | SD at CHW | 1-6 | Chicago White Sox | Preseason |
| Mar 11, 2016 | CHW at SD | 8-3 | Chicago White Sox | Preseason |
| Mar 6, 2016 | SD at CHW | 1-8 | Chicago White Sox | Preseason |
| Apr 1, 2015 | SD at CHW | 8-2 | San Diego Padres | Preseason |
| Mar 23, 2015 | CHW at SD | 4-10 | San Diego Padres | Preseason |
| Mar 6, 2015 | CHW at SD | 0-5 | San Diego Padres | Preseason |
| Jun 1, 2014 | SD at CHW | 1-4 | Chicago White Sox | Regular |
| May 31, 2014 | SD at CHW | 4-2 | San Diego Padres | Regular |
| May 30, 2014 | SD at CHW | 4-1 | San Diego Padres | Regular |
| Mar 22, 2014 | CHW at SD | 3-3 | Chicago White Sox | Preseason |
| Mar 5, 2014 | SD at CHW | 8-0 | San Diego Padres | Preseason |
| Mar 3, 2013 | CHW at SD | 0-4 | San Diego Padres | Preseason |
| Mar 28, 2012 | SD at CHW | 13-2 | San Diego Padres | Preseason |
| Mar 13, 2012 | CHW at SD | 3-6 | San Diego Padres | Preseason |
| Mar 21, 2011 | CHW at SD | 8-5 | Chicago White Sox | Preseason |
| Mar 14, 2011 | SD at CHW | 7-6 | San Diego Padres | Preseason |
| Mar 25, 2010 | CHW at SD | 3-5 | San Diego Padres | Preseason |
| Mar 20, 2010 | SD at CHW | 4-1 | San Diego Padres | Preseason |
| Apr 1, 2009 | SD at CHW | 6-1 | San Diego Padres | Preseason |
| Mar 13, 2009 | CHW at SD | 15-4 | Chicago White Sox | Preseason |
| Mar 18, 2008 | SD at CHW | 5-0 | San Diego Padres | Preseason |
| Mar 9, 2008 | CHW at SD | 3-12 | San Diego Padres | Preseason |
| Mar 18, 2007 | CHW at SD | 14-7 | Chicago White Sox | Preseason |
| Mar 12, 2007 | SD at CHW | 10-8 | San Diego Padres | Preseason |
| Mar 21, 2006 | SD at CHW | 10-7 | San Diego Padres | Preseason |
| Jun 12, 2005 | CHW at SD | 8-5 | Chicago White Sox | Regular |
| Jun 11, 2005 | CHW at SD | 1-2 | San Diego Padres | Regular |
| Jun 10, 2005 | CHW at SD | 4-2 | Chicago White Sox | Regular |
| Mar 11, 2005 | SD at CHW | 3-6 | Chicago White Sox | Preseason |
| Mar 9, 2005 | CHW at SD | 7-3 | Chicago White Sox | Preseason |
| Mar 31, 2004 | CHW at SD | 15-11 | Chicago White Sox | Preseason |
| Mar 11, 2004 | SD at CHW | 5-4 | San Diego Padres | Preseason |
| Jun 15, 2003 | SD at CHW | 1-0 | San Diego Padres | Regular |
| Jun 14, 2003 | SD at CHW | 5-6 | Chicago White Sox | Regular |
| Jun 13, 2003 | SD at CHW | 3-5 | Chicago White Sox | Regular |
| Mar 7, 2003 | SD at CHW | 0-2 | Chicago White Sox | Preseason |
| Mar 5, 2003 | CHW at SD | 11-6 | Chicago White Sox | Preseason |
| Mar 14, 2002 | CHW at SD | 8-11 | San Diego Padres | Preseason |
| Mar 4, 2002 | SD at CHW | 14-9 | San Diego Padres | Preseason |
| Mar 20, 2001 | SD at CHW | 3-1 | San Diego Padres | Preseason |
| Mar 11, 2001 | CHW at SD | 6-1 | Chicago White Sox | Preseason |
| Mar 18, 2000 | SD at CHW | 10-5 | San Diego Padres | Preseason |
| Mar 9, 2000 | CHW at SD | 7-1 | Chicago White Sox | Preseason |
Completed games on file, which start in 2000 — not the clubs’ full all-time series. Regular season 85, postseason 0.