Buffalo Bills players with a 1,000+ rushing yards season
9 players have had a 1,000+ rushing yards season for the Buffalo Bills. Thurman Thomas did it the most, 8 times (1989–1996), the best at 1,487 rushing yards. On a roster now: James Cook III.
| Player | Pos | Seasons | Best |
|---|---|---|---|
| Thurman Thomas | RB | 1989–1996 | 1,487 |
| James Cook III | RB | 2023–2025 | 1,621 |
| Travis Henry | RB | 2002–2003 | 1,438 |
| LeSean McCoy | RB | 2016–2017 | 1,267 |
| Willis McGahee | RB | 2004–2005 | 1,247 |
| Marshawn Lynch | RB | 2007–2008 | 1,115 |
| C.J. Spiller | RB | 2012 | 1,244 |
| Antowain Smith | RB | 1998 | 1,124 |
| Fred Jackson | RB | 2009 | 1,062 |
Reached with the club in one regular season. Seasons are on file in full from 1993; before that only some of the stars are, so an older name can be missing.