Jacksonville Jaguars vs San Francisco 49ers head-to-head
Who has won more, the Jacksonville Jaguars or the San Francisco 49ers?
San Francisco 49ers lead the series 5-3 in 8 meetings since Sep 12, 1999. They average 17.0 to 25.4. The last meeting was Sep 28, 2025, 26-21.
- Record
- Jacksonville Jaguars 3-5 San Francisco 49ers
- Games
- 8
- Points per game
- 17.0 – 25.4
- Biggest win
- Jacksonville Jaguars by 38
Every meeting on file
| Sep 28, 2025 |  JAX at  SF | 26-21 | Jacksonville Jaguars | Regular |
| Nov 12, 2023 | SF at JAX | 34-3 | San Francisco 49ers | Regular |
| Nov 21, 2021 | SF at JAX | 30-10 | San Francisco 49ers | Regular |
| Dec 24, 2017 | JAX at SF | 33-44 | San Francisco 49ers | Regular |
| Oct 27, 2013 | SF at JAX | 42-10 | San Francisco 49ers | Regular |
| Nov 29, 2009 | JAX at SF | 3-20 | San Francisco 49ers | Regular |
| Dec 18, 2005 | SF at JAX | 9-10 | Jacksonville Jaguars | Regular |
| Sep 12, 1999 | SF at JAX | 3-41 | Jacksonville Jaguars | Regular |
Completed games on file, which start in 1999 — not the clubs’ full all-time series. Regular season 8, postseason 0.