Indianapolis Colts vs San Francisco 49ers head-to-head
Who has won more, the Indianapolis Colts or the San Francisco 49ers?
Indianapolis Colts lead the series 7-6 in 13 meetings since Oct 5, 1986. They average 23.4 to 24.8. The last meeting was Dec 22, 2025, 48-27.
- Record
- Indianapolis Colts 7-6 San Francisco 49ers
- Games
- 13
- Points per game
- 23.4 – 24.8
- Biggest win
- Indianapolis Colts by 25
Every meeting on file
| Dec 22, 2025 |  SF at  IND | 48-27 | San Francisco 49ers | Regular |
| Oct 24, 2021 | IND at SF | 30-18 | Indianapolis Colts | Regular |
| Aug 25, 2018 | SF at IND | 17-23 | Indianapolis Colts | Preseason |
| Oct 8, 2017 | SF at IND | 23-26 | Indianapolis Colts | Regular |
| Sep 22, 2013 | IND at SF | 27-7 | Indianapolis Colts | Regular |
| Aug 15, 2010 | SF at IND | 37-17 | San Francisco 49ers | Preseason |
| Nov 1, 2009 | SF at IND | 14-18 | Indianapolis Colts | Regular |
| Oct 9, 2005 | IND at SF | 28-3 | Indianapolis Colts | Regular |
| Nov 25, 2001 | SF at IND | 40-21 | San Francisco 49ers | Regular |
| Oct 18, 1998 | IND at SF | 31-34 | San Francisco 49ers | Regular |
| Oct 15, 1995 | SF at IND | 17-18 | Indianapolis Colts | Regular |
| Sep 10, 1989 | SF at IND | 30-24 | San Francisco 49ers | Regular |
| Oct 5, 1986 | IND at SF | 14-35 | San Francisco 49ers | Regular |
Completed games on file, which start in 1986 — not the clubs’ full all-time series. Regular season 13, postseason 0.