Houston Texans vs San Francisco 49ers head-to-head
Who has won more, the Houston Texans or the San Francisco 49ers?
Houston Texans lead the series 8-5 in 13 meetings since Jan 1, 2006. They average 18.2 to 17.8. The last meeting was Oct 26, 2025, 26-15.
- Record
- Houston Texans 8-5 San Francisco 49ers
- Games
- 13
- Points per game
- 18.2 – 17.8
- Biggest win
- San Francisco 49ers by 31
Houston Texans have won the last 2 meetings.
Every meeting on file
| Oct 26, 2025 |  SF at  HOU | 15-26 | Houston Texans | Regular |
| Aug 25, 2022 | SF at HOU | 0-17 | Houston Texans | Preseason |
| Jan 2, 2022 | HOU at SF | 7-23 | San Francisco 49ers | Regular |
| Aug 18, 2018 | SF at HOU | 13-16 | Houston Texans | Preseason |
| Dec 10, 2017 | SF at HOU | 26-16 | San Francisco 49ers | Regular |
| Aug 14, 2016 | HOU at SF | 24-13 | Houston Texans | Preseason |
| Aug 15, 2015 | SF at HOU | 10-23 | Houston Texans | Preseason |
| Aug 28, 2014 | SF at HOU | 40-13 | San Francisco 49ers | Preseason |
| Oct 6, 2013 | HOU at SF | 3-34 | San Francisco 49ers | Regular |
| Aug 18, 2012 | SF at HOU | 9-20 | Houston Texans | Preseason |
| Aug 27, 2011 | HOU at SF | 30-7 | Houston Texans | Preseason |
| Oct 25, 2009 | SF at HOU | 21-24 | Houston Texans | Regular |
| Jan 1, 2006 | HOU at SF | 17-20 | San Francisco 49ers | Regular |
Completed games on file, which start in 2005 — not the clubs’ full all-time series. Regular season 13, postseason 0.