Denver Broncos vs San Francisco 49ers head-to-head
Who has won more, the Denver Broncos or the San Francisco 49ers?
Denver Broncos lead the series 16-13 in 31 meetings since Oct 25, 1970. They average 21.3 to 18.5. The last meeting was Aug 9, 2025, 30-9.
- Record
- Denver Broncos 16-13-2 San Francisco 49ers
- Games
- 31
- Points per game
- 21.3 – 18.5
- Biggest win
- San Francisco 49ers by 45
1 of those 31 games were in the postseason.
Every meeting on file
| Aug 9, 2025 |  DEN at  SF | 30-9 | Denver Broncos | Preseason |
| Aug 19, 2023 | DEN at SF | 20-21 | San Francisco 49ers | Preseason |
| Sep 25, 2022 | SF at DEN | 10-11 | Denver Broncos | Regular |
| Aug 19, 2019 | SF at DEN | 24-15 | San Francisco 49ers | Preseason |
| Dec 9, 2018 | DEN at SF | 14-20 | San Francisco 49ers | Regular |
| Aug 19, 2017 | DEN at SF | 33-14 | Denver Broncos | Preseason |
| Aug 20, 2016 | SF at DEN | 31-24 | San Francisco 49ers | Preseason |
| Aug 29, 2015 | SF at DEN | 12-19 | Denver Broncos | Preseason |
| Oct 19, 2014 | SF at DEN | 17-42 | Denver Broncos | Regular |
| Aug 17, 2014 | DEN at SF | 34-0 | Denver Broncos | Preseason |
| Aug 8, 2013 | DEN at SF | 10-6 | Denver Broncos | Preseason |
| Aug 26, 2012 | SF at DEN | 29-24 | San Francisco 49ers | Preseason |
| Oct 31, 2010 | DEN at SF | 16-24 | San Francisco 49ers | Regular |
| Aug 14, 2009 | DEN at SF | 16-17 | San Francisco 49ers | Preseason |
| Aug 13, 2007 | DEN at SF | 17-13 | Denver Broncos | Preseason |
| Dec 31, 2006 | SF at DEN | 26-23 | San Francisco 49ers | Regular |
| Aug 20, 2005 | SF at DEN | 21-26 | Denver Broncos | Preseason |
| Sep 15, 2002 | DEN at SF | 24-14 | Denver Broncos | Regular |
| Aug 19, 2002 | SF at DEN | 12-7 | San Francisco 49ers | Preseason |
| Aug 31, 2001 | SF at DEN | 7-35 | Denver Broncos | Preseason |
| Dec 23, 2000 | SF at DEN | 9-38 | Denver Broncos | Regular |
| Aug 25, 2000 | DEN at SF | 28-24 | Denver Broncos | Preseason |
| Dec 15, 1997 | DEN at SF | 0-0 | Denver Broncos | Regular |
| Dec 17, 1994 | DEN at SF | 19-42 | San Francisco 49ers | Regular |
| Jan 28, 1990 | SF at DEN | 55-10 | San Francisco 49ers | Postseason |
| Oct 9, 1988 | DEN at SF | 16-13 | Denver Broncos | Regular |
| Nov 11, 1985 | SF at DEN | 0-0 | San Francisco 49ers | Regular |
| Sep 19, 1982 | SF at DEN | 21-24 | Denver Broncos | Regular |
| Nov 18, 1979 | DEN at SF | 38-28 | Denver Broncos | Regular |
| Sep 23, 1973 | SF at DEN | 36-34 | San Francisco 49ers | Regular |
| Oct 25, 1970 | DEN at SF | 14-19 | San Francisco 49ers | Regular |
Completed games on file, which start in 1970 — not the clubs’ full all-time series. Regular season 30, postseason 1.