Carolina Panthers vs San Francisco 49ers head-to-head
Who has won more, the Carolina Panthers or the San Francisco 49ers?
Carolina Panthers lead the series 13-10 in 24 meetings since Nov 5, 1995. They average 22.6 to 21.8. The last meeting was Nov 24, 2025, 20-9.
- Record
- Carolina Panthers 13-10-1 San Francisco 49ers
- Games
- 24
- Points per game
- 22.6 – 21.8
- Biggest win
- San Francisco 49ers by 38
San Francisco 49ers have won the last 3 meetings.
1 of those 24 games were in the postseason.
Every meeting on file
| Nov 24, 2025 |  CAR at  SF | 9-20 | San Francisco 49ers | Regular |
| Oct 9, 2022 | SF at CAR | 37-15 | San Francisco 49ers | Regular |
| Oct 27, 2019 | CAR at SF | 13-51 | San Francisco 49ers | Regular |
| Sep 10, 2017 | CAR at SF | 23-3 | Carolina Panthers | Regular |
| Sep 18, 2016 | SF at CAR | 27-46 | Carolina Panthers | Regular |
| Jan 12, 2014 | SF at CAR | 23-10 | San Francisco 49ers | Postseason |
| Nov 10, 2013 | CAR at SF | 10-9 | Carolina Panthers | Regular |
| Oct 24, 2010 | SF at CAR | 20-23 | Carolina Panthers | Regular |
| Dec 2, 2007 | SF at CAR | 14-31 | Carolina Panthers | Regular |
| Nov 14, 2004 | CAR at SF | 37-27 | Carolina Panthers | Regular |
| Nov 18, 2001 | SF at CAR | 25-22 | San Francisco 49ers | Regular |
| Oct 7, 2001 | CAR at SF | 14-24 | San Francisco 49ers | Regular |
| Oct 22, 2000 | SF at CAR | 16-34 | Carolina Panthers | Regular |
| Sep 10, 2000 | CAR at SF | 38-22 | Carolina Panthers | Regular |
| Dec 18, 1999 | SF at CAR | 24-41 | Carolina Panthers | Regular |
| Oct 17, 1999 | CAR at SF | 31-29 | Carolina Panthers | Regular |
| Dec 6, 1998 | SF at CAR | 31-28 | San Francisco 49ers | Regular |
| Nov 8, 1998 | CAR at SF | 23-25 | San Francisco 49ers | Regular |
| Nov 16, 1997 | CAR at SF | 19-27 | San Francisco 49ers | Regular |
| Sep 29, 1997 | SF at CAR | 0-0 | San Francisco 49ers | Regular |
| Dec 8, 1996 | CAR at SF | 30-24 | Carolina Panthers | Regular |
| Sep 22, 1996 | SF at CAR | 7-23 | Carolina Panthers | Regular |
| Dec 10, 1995 | SF at CAR | 31-10 | San Francisco 49ers | Regular |
| Nov 5, 1995 | CAR at SF | 13-7 | Carolina Panthers | Regular |
Completed games on file, which start in 1995 — not the clubs’ full all-time series. Regular season 23, postseason 1.