Buffalo Bills vs Detroit Lions head-to-head
Who has won more, the Buffalo Bills or the Detroit Lions?
Detroit Lions lead the series 23-18 in 42 meetings since Oct 8, 1972. They average 18.7 to 21.1. The last meeting was Sep 17, 2026, 41-31.
- Record
- Buffalo Bills 18-23-1 Detroit Lions
- Games
- 42
- Points per game
- 18.7 – 21.1
- Biggest win
- Detroit Lions by 31
Buffalo Bills have won the last 7 meetings.
Every meeting on file
| Sep 17, 2026 |  DET at  BUF | 31-41 | Buffalo Bills | Regular |
| Dec 15, 2024 | BUF at DET | 48-42 | Buffalo Bills | Regular |
| Nov 24, 2022 | BUF at DET | 28-25 | Buffalo Bills | Regular |
| Aug 13, 2021 | BUF at DET | 16-15 | Buffalo Bills | Preseason |
| Aug 23, 2019 | BUF at DET | 24-20 | Buffalo Bills | Preseason |
| Dec 16, 2018 | DET at BUF | 13-14 | Buffalo Bills | Regular |
| Aug 31, 2017 | DET at BUF | 17-27 | Buffalo Bills | Preseason |
| Sep 1, 2016 | BUF at DET | 0-31 | Detroit Lions | Preseason |
| Sep 3, 2015 | BUF at DET | 10-17 | Detroit Lions | Preseason |
| Oct 5, 2014 | BUF at DET | 17-14 | Buffalo Bills | Regular |
| Aug 28, 2014 | DET at BUF | 23-0 | Detroit Lions | Preseason |
| Aug 29, 2013 | DET at BUF | 35-13 | Detroit Lions | Preseason |
| Aug 30, 2012 | BUF at DET | 32-38 | Detroit Lions | Preseason |
| Sep 1, 2011 | DET at BUF | 16-6 | Detroit Lions | Preseason |
| Nov 14, 2010 | DET at BUF | 12-14 | Buffalo Bills | Regular |
| Sep 2, 2010 | BUF at DET | 23-28 | Detroit Lions | Preseason |
| Sep 3, 2009 | DET at BUF | 17-6 | Detroit Lions | Preseason |
| Aug 28, 2008 | DET at BUF | 14-6 | Detroit Lions | Preseason |
| Aug 30, 2007 | BUF at DET | 16-13 | Buffalo Bills | Preseason |
| Oct 15, 2006 | BUF at DET | 17-20 | Detroit Lions | Regular |
| Aug 31, 2006 | BUF at DET | 20-13 | Buffalo Bills | Preseason |
| Sep 2, 2005 | DET at BUF | 21-7 | Detroit Lions | Preseason |
| Sep 2, 2004 | BUF at DET | 17-20 | Detroit Lions | Preseason |
| Aug 28, 2003 | DET at BUF | 16-22 | Buffalo Bills | Preseason |
| Oct 27, 2002 | DET at BUF | 17-24 | Buffalo Bills | Regular |
| Aug 29, 2002 | BUF at DET | 13-20 | Detroit Lions | Preseason |
| Aug 12, 2000 | BUF at DET | 13-15 | Detroit Lions | Preseason |
| Oct 5, 1997 | DET at BUF | 13-22 | Buffalo Bills | Regular |
| Nov 24, 1994 | BUF at DET | 21-35 | Detroit Lions | Regular |
| Dec 22, 1991 | DET at BUF | 17-14 | Detroit Lions | Regular |
| Dec 24, 1989 | DET at BUF | 31-24 | Detroit Lions | Regular |
| Dec 27, 1987 | DET at BUF | 30-13 | Detroit Lions | Regular |
| Sep 8, 1985 | DET at BUF | 28-27 | Detroit Lions | Regular |
| Sep 9, 1984 | DET at BUF | 27-24 | Detroit Lions | Regular |
| Oct 5, 1980 | DET at BUF | 28-43 | Buffalo Bills | Regular |
| Oct 28, 1979 | BUF at DET | 20-17 | Buffalo Bills | Regular |
| Oct 15, 1978 | DET at BUF | 0-14 | Buffalo Bills | Regular |
| Nov 13, 1977 | DET at BUF | 6-17 | Buffalo Bills | Regular |
| Nov 25, 1976 | BUF at DET | 14-27 | Detroit Lions | Regular |
| Sep 28, 1975 | DET at BUF | 17-14 | Detroit Lions | Regular |
| Dec 10, 1972 | DET at BUF | 21-21 | Detroit Lions | Regular |
| Oct 8, 1972 | DET at BUF | 26-23 | Detroit Lions | Regular |
Completed games on file, which start in 1972 — not the clubs’ full all-time series. Regular season 42, postseason 0.