Arizona Cardinals vs San Francisco 49ers head-to-head
Who has won more, the Arizona Cardinals or the San Francisco 49ers?
San Francisco 49ers lead the series 35-28 in 64 meetings since Oct 24, 1971. They average 20.4 to 23.5. The last meeting was Nov 16, 2025, 41-22.
- Record
- Arizona Cardinals 28-35-1 San Francisco 49ers
- Games
- 64
- Points per game
- 20.4 – 23.5
- Biggest win
- Arizona Cardinals by 40
San Francisco 49ers have won the last 2 meetings.
Every meeting on file
| Nov 16, 2025 |  SF at  ARI | 41-22 | San Francisco 49ers | Regular |
| Sep 21, 2025 | ARI at SF | 15-16 | San Francisco 49ers | Regular |
| Jan 5, 2025 | SF at ARI | 24-47 | Arizona Cardinals | Regular |
| Oct 6, 2024 | ARI at SF | 24-23 | Arizona Cardinals | Regular |
| Dec 17, 2023 | SF at ARI | 45-29 | San Francisco 49ers | Regular |
| Oct 1, 2023 | ARI at SF | 16-35 | San Francisco 49ers | Regular |
| Jan 8, 2023 | ARI at SF | 13-38 | San Francisco 49ers | Regular |
| Nov 21, 2022 | SF at ARI | 38-10 | San Francisco 49ers | Regular |
| Nov 7, 2021 | ARI at SF | 31-17 | Arizona Cardinals | Regular |
| Oct 10, 2021 | SF at ARI | 10-17 | Arizona Cardinals | Regular |
| Dec 26, 2020 | SF at ARI | 20-12 | San Francisco 49ers | Regular |
| Sep 13, 2020 | ARI at SF | 24-20 | Arizona Cardinals | Regular |
| Nov 17, 2019 | ARI at SF | 26-36 | San Francisco 49ers | Regular |
| Oct 31, 2019 | SF at ARI | 28-25 | San Francisco 49ers | Regular |
| Oct 28, 2018 | SF at ARI | 15-18 | Arizona Cardinals | Regular |
| Oct 7, 2018 | ARI at SF | 28-18 | Arizona Cardinals | Regular |
| Nov 5, 2017 | ARI at SF | 20-10 | Arizona Cardinals | Regular |
| Oct 1, 2017 | SF at ARI | 15-18 | Arizona Cardinals | Regular |
| Nov 13, 2016 | SF at ARI | 20-23 | Arizona Cardinals | Regular |
| Oct 6, 2016 | ARI at SF | 33-21 | Arizona Cardinals | Regular |
| Nov 29, 2015 | ARI at SF | 19-13 | Arizona Cardinals | Regular |
| Sep 27, 2015 | SF at ARI | 7-47 | Arizona Cardinals | Regular |
| Dec 28, 2014 | ARI at SF | 17-20 | San Francisco 49ers | Regular |
| Sep 21, 2014 | SF at ARI | 14-23 | Arizona Cardinals | Regular |
| Dec 29, 2013 | SF at ARI | 23-20 | San Francisco 49ers | Regular |
| Oct 13, 2013 | ARI at SF | 20-32 | San Francisco 49ers | Regular |
| Dec 30, 2012 | ARI at SF | 13-27 | San Francisco 49ers | Regular |
| Oct 29, 2012 | SF at ARI | 24-3 | San Francisco 49ers | Regular |
| Dec 11, 2011 | SF at ARI | 19-21 | Arizona Cardinals | Regular |
| Nov 20, 2011 | ARI at SF | 7-23 | San Francisco 49ers | Regular |
| Jan 2, 2011 | ARI at SF | 7-38 | San Francisco 49ers | Regular |
| Nov 29, 2010 | SF at ARI | 27-6 | San Francisco 49ers | Regular |
| Dec 14, 2009 | ARI at SF | 9-24 | San Francisco 49ers | Regular |
| Sep 13, 2009 | SF at ARI | 20-16 | San Francisco 49ers | Regular |
| Nov 10, 2008 | SF at ARI | 24-29 | Arizona Cardinals | Regular |
| Sep 7, 2008 | ARI at SF | 23-13 | Arizona Cardinals | Regular |
| Nov 25, 2007 | SF at ARI | 37-31 | San Francisco 49ers | Regular |
| Sep 10, 2007 | ARI at SF | 17-20 | San Francisco 49ers | Regular |
| Dec 24, 2006 | ARI at SF | 26-20 | Arizona Cardinals | Regular |
| Sep 10, 2006 | SF at ARI | 27-34 | Arizona Cardinals | Regular |
| Dec 4, 2005 | ARI at SF | 17-10 | Arizona Cardinals | Regular |
| Oct 2, 2005 | SF at ARI | 14-31 | Arizona Cardinals | Regular |
| Dec 12, 2004 | SF at ARI | 31-28 | San Francisco 49ers | Regular |
| Oct 10, 2004 | ARI at SF | 28-31 | San Francisco 49ers | Regular |
| Dec 7, 2003 | ARI at SF | 14-50 | San Francisco 49ers | Regular |
| Oct 26, 2003 | SF at ARI | 13-16 | Arizona Cardinals | Regular |
| Dec 21, 2002 | SF at ARI | 17-14 | San Francisco 49ers | Regular |
| Oct 27, 2002 | ARI at SF | 28-38 | San Francisco 49ers | Regular |
| Oct 1, 2000 | ARI at SF | 20-27 | San Francisco 49ers | Regular |
| Sep 27, 1999 | SF at ARI | 0-0 | San Francisco 49ers | Regular |
| Oct 24, 1993 | ARI at SF | 14-28 | San Francisco 49ers | Regular |
| Nov 1, 1992 | SF at ARI | 14-24 | Arizona Cardinals | Regular |
| Nov 17, 1991 | ARI at SF | 10-14 | San Francisco 49ers | Regular |
| Nov 6, 1988 | SF at ARI | 23-24 | Arizona Cardinals | Regular |
| Oct 18, 1987 | ARI at SF | 28-34 | San Francisco 49ers | Regular |
| Nov 9, 1986 | ARI at SF | 17-43 | San Francisco 49ers | Regular |
| Sep 18, 1983 | SF at ARI | 42-27 | San Francisco 49ers | Regular |
| Nov 21, 1982 | SF at ARI | 31-20 | San Francisco 49ers | Regular |
| Sep 14, 1980 | ARI at SF | 7-24 | San Francisco 49ers | Regular |
| Dec 2, 1979 | SF at ARI | 10-13 | Arizona Cardinals | Regular |
| Nov 12, 1978 | ARI at SF | 16-10 | Arizona Cardinals | Regular |
| Oct 31, 1976 | SF at ARI | 20-23 | Arizona Cardinals | Regular |
| Oct 6, 1974 | ARI at SF | 34-9 | Arizona Cardinals | Regular |
| Oct 24, 1971 | SF at ARI | 26-14 | San Francisco 49ers | Regular |
Completed games on file, which start in 1971 — not the clubs’ full all-time series. Regular season 64, postseason 0.