The Buffalo Bills beat the San Francisco 49ers 45-16 on Oct 16, 2016 at Highmark Stadium (Old).
Final · Highmark Stadium (Old)
No player lines are on file for this game, only the final score.
Before and after
- 49ers · 2016 season · Previous Oct 6, 2016: ARI 33, SF 21 · Next Oct 23, 2016: TB 34, SF 17
- Bills · 2016 season · Previous Oct 9, 2016: BUF 30, LAR 19 · Next Oct 23, 2016: BUF 25, MIA 28