Cowboys 21, Cyclones 24
Final · FOX · Jack Trice Stadium · Attendance 61,500
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 OKST | 7 | 7 | 0 | 7 | 21 |
 ISU | 0 | 7 | 10 | 7 | 24 |
The Iowa State Cyclones beat the Oklahoma State Cowboys 24-21 on Oct 23, 2021 at Jack Trice Stadium.
Top performers
Spencer Sanders threw for 225 yards, 3 touchdowns and 0 interceptions for the Cowboys.
Jaylen Warren ran for 76 yards on 18 carries.
Brock Purdy threw for 307 yards, 2 touchdowns and 0 interceptions for the Cyclones.
Breece Hall ran for 70 yards on 21 carries.
Before and after
- Cowboys · 2021 season · Previous Oct 16, 2021: OKST 32, TEX 24 · Next Oct 30, 2021: KU 3, OKST 55
- Cyclones · 2021 season · Previous Oct 16, 2021: ISU 33, KSU 20 · Next Oct 30, 2021: ISU 31, WVU 38
Other Cowboys vs Cyclones games
| Nov 29, 2025 | ISU at OKST | 20-13 | Regular |
| Sep 23, 2023 | OKST at ISU | 27-34 | Regular |
| Nov 12, 2022 | ISU at OKST | 14-20 | Regular |
| Oct 24, 2020 | ISU at OKST | 21-24 | Regular |
| Oct 26, 2019 | OKST at ISU | 34-27 | Regular |
| Oct 6, 2018 | ISU at OKST | 48-42 | Regular |
